Photobiology Laboratory of the Medical University of South Africa, 2005
Objective To evaluate the efficacy of Bio-Oil in improving the appearance of facial melasma, a mottled pigmentation related to hormonal changes.
Sample: 30 female participants (15 Caucasian and 15 Black African) between the ages of 18 and 55.
Method: Single blind, single product, randomized and controlled. Bio‑Oil was applied twice daily to All sites were facial melasma. Bilateral pigmentation was chosen to allow half-face study design with intra-subject comparison. No additional massaging performed on the treated area. No treatment applied to the other half of the affected area. Statistical tests conducted to measure difference in color of the skin on the pigmented area compared to the background skin color and to the untreated area.
Result: Bio‑Oil improved the appearance of uneven skin tone in both light and dark skin types. 93% of subjects recorded an improvement in appearance at 6 weeks. Clinician noted an equal improvement in both light and dark skin types from week 0 to 8. Clinician noted more improvement in dark skin types from week 8 to 12.
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Thomas J. Stephens & Associates, Inc., Texas, USA, 2011
Objective: To evaluate the efficacy of Bio-Oil in improving the appearance of uneven skin tone and mottled pigmentation when used by women with mild to moderate photodamaged (aging) skin on the face and neck.
Sample: 67 female participants, of varying ethnicities, with clinically determined mild to moderate photodamage on the face and neck. Bio-Oil treatment cell included 35 subjects and the no treatment cell included 32 subjects. Age of participants: 30-70.
Method: Randomized, controlled, efficacy grader blinded. Subjects participated in an initial screening evaluation followed by a 1-week washout period. Product applied to the face and neck twice daily for 12 weeks. Application performed under supervision at baseline visit. Clinical evaluations conducted at 0, 2, 4, 8 and 12 weeks. Subjects were clinically graded separately on the face and neck for uneven skin tone and mottled pigmentation.
Result: Bio-Oil is efficacious in improving the appearance of uneven skin tone and mottled pigmentation in photodamaged (aging) skin. After 4 weeks a statistically significant result was achieved for both parameters on the face and neck. After 12 weeks 86% of subjects in the Bio-Oil treatment cell showed a statistically significant improvement in uneven skin tone on the face, 71% of subjects in mottled pigmentation on the face, 69% in uneven skin tone on the neck.
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